{"id":1312,"date":"2020-11-15T12:41:16","date_gmt":"2020-11-15T12:41:16","guid":{"rendered":"https:\/\/nebfeupicbas.pt\/?p=1312"},"modified":"2020-11-15T13:30:54","modified_gmt":"2020-11-15T13:30:54","slug":"bionow-5-nanoparticulas-em-vacina-proteica-contra-o-sars-cov-2","status":"publish","type":"post","link":"https:\/\/nebfeupicbas.pt\/?p=1312","title":{"rendered":"BioNOW! #5 &#8211; Nanopart\u00edculas em vacina proteica contra o SARS-CoV-2"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1312\" class=\"elementor elementor-1312\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6339162d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6339162d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6aa78706\" data-id=\"6aa78706\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-741b7d5 elementor-widget elementor-widget-heading\" data-id=\"741b7d5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">BioNOW! #5 \u2013 Nanopart\u00edculas em vacina proteica contra o SARS-CoV-2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12599fd elementor-widget elementor-widget-text-editor\" data-id=\"12599fd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>O fim da pandemia de COVID-19 que a humanidade est\u00e1 a atravessar passa, indubitavelmente, pelo desenvolvimento de uma vacina segura e eficaz. As nanopart\u00edculas podem vir a ser a chave para esse objetivo.<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d444c21 elementor-widget elementor-widget-text-editor\" data-id=\"1d444c21\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<p>A maioria das vacinas contra o SARS-CoV-2 que est\u00e3o a ser desenvolvidas usa uma de tr\u00eas abordagens \u2013 inocula\u00e7\u00e3o de prote\u00ednas do v\u00edrus, de material gen\u00e9tico do mesmo (mRNA), ou de c\u00f3pias inativadas do v\u00edrus inteiro. Apesar das vacinas-candidatas mais avan\u00e7adas nos ensaios cl\u00ednicos utilizarem a tecnologia de mRNA, esta \u00e9 muito mais recente do que as vacinas proteicas. As incertezas que isso levanta motivam a investiga\u00e7\u00e3o a continuar em todas as frentes.<\/p>\n<p>Nesse contexto, um grupo de investiga\u00e7\u00e3o da universidade de Washington, em Seattle, desenvolveu uma nova vacina proteica, que desencadeou uma resposta imune muito promissora nos ensaios em ratinho, recorrendo a nanopart\u00edculas para organizar as prote\u00ednas numa forma semelhante \u00e0 do v\u00edrus intacto. A inocula\u00e7\u00e3o das vacinas assim produzidas levou a concentra\u00e7\u00f5es de anticorpos no sangue dez vezes superiores \u00e0s obtidas com a inocula\u00e7\u00e3o da prote\u00edna livre, usando uma dose cinco vezes menor.<\/p>\n<p><\/p>\n<p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49363e6 elementor-widget elementor-widget-image\" data-id=\"49363e6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"284\" height=\"296\" src=\"https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2020\/11\/bionow_5_image_1.jpg\" class=\"attachment-large size-large wp-image-1315\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69d0702 elementor-widget elementor-widget-text-editor\" data-id=\"69d0702\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Figura 1 \u2013 Modelo estrutural das nanopart\u00edculas utilizadas neste estudo.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ee8570 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ee8570\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f50abbd\" data-id=\"f50abbd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-00b4f63 elementor-widget elementor-widget-text-editor\" data-id=\"00b4f63\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<p>As nanopart\u00edculas usadas nesse trabalho s\u00e3o esferas proteicas com 28 nm de di\u00e2metro e as prote\u00ednas que as constituem foram geradas pela express\u00e3o recombinante dos genes que as codificam, fundidos com o gene de um dom\u00ednio da prote\u00edna <em>Spike <\/em>do SARS-CoV-2. Este m\u00e9todo leva \u00e0 exposi\u00e7\u00e3o desses dom\u00ednios na superf\u00edcie da nanopart\u00edcula, tal como acontece no v\u00edrus.<\/p>\n<p><\/p>\n<p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4382550 elementor-widget elementor-widget-image\" data-id=\"4382550\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"700\" height=\"389\" src=\"https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2020\/11\/bionow_5_image_2-700x389.jpg\" class=\"attachment-large size-large wp-image-1316\" alt=\"\" srcset=\"https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2020\/11\/bionow_5_image_2-700x389.jpg 700w, https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2020\/11\/bionow_5_image_2-300x167.jpg 300w, https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2020\/11\/bionow_5_image_2-768x426.jpg 768w, https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2020\/11\/bionow_5_image_2.jpg 996w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c82a79 elementor-widget elementor-widget-text-editor\" data-id=\"8c82a79\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Figura 2 &#8211; Resumo gr\u00e1fico do modo de funcionamento desta vacina de nanopart\u00edculas. A nanopart\u00edcula proteica recoberta de RBD (receptor-binding domain) da prote\u00edna <em>Spike<\/em> estimula as c\u00e9lulas produtoras de anticorpos com uma efic\u00e1cia muito superior aos RBD livres.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53cb32c elementor-widget elementor-widget-text-editor\" data-id=\"53cb32c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A promo\u00e7\u00e3o de uma resposta imune com grande concentra\u00e7\u00e3o de anticorpos e elevada taxa de anticorpos neutralizantes, especialmente em compara\u00e7\u00e3o com a inocula\u00e7\u00e3o da prote\u00edna <em>Spike<\/em> livre, \u00e9 explicada pela concentra\u00e7\u00e3o de v\u00e1rios dom\u00ednios proteicos imunog\u00e9nicos num pequeno espa\u00e7o, que leva a uma maior estimula\u00e7\u00e3o das c\u00e9lulas imunes.<\/p>\n<p>Estes resultados, que mostram a imuniza\u00e7\u00e3o eficaz de animais com a inocula\u00e7\u00e3o de uma pequena dose destas nanopart\u00edculas, tornam-nas muito promissoras e com potencial para terem um grande impacto econ\u00f3mico e na sa\u00fade p\u00fablica. Por essa raz\u00e3o, est\u00e3o a ser fabricadas doses de vacina para ensaios cl\u00ednicos no futuro pr\u00f3ximo.<\/p>\n<p><\/p>\n<p>Sabe mais em: <br \/><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2020.10.043\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.cell.2020.10.043<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>O fim da pandemia de COVID-19 que a humanidade est\u00e1 a atravessar passa, indubitavelmente, pelo desenvolvimento de uma vacina segura e eficaz. As nanopart\u00edculas podem vir a ser a chave para esse objetivo.<\/p>\n","protected":false},"author":4,"featured_media":1314,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-1312","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bionow"],"_links":{"self":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts\/1312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1312"}],"version-history":[{"count":6,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts\/1312\/revisions"}],"predecessor-version":[{"id":1321,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts\/1312\/revisions\/1321"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/media\/1314"}],"wp:attachment":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}