{"id":1425,"date":"2021-01-10T20:41:44","date_gmt":"2021-01-10T20:41:44","guid":{"rendered":"https:\/\/nebfeupicbas.pt\/?p=1425"},"modified":"2021-01-10T22:22:49","modified_gmt":"2021-01-10T22:22:49","slug":"bionow-13-terapia-genetica-como-cura-para-a-surdez","status":"publish","type":"post","link":"https:\/\/nebfeupicbas.pt\/?p=1425","title":{"rendered":"BioNOW! #13 &#8211; Terapia gen\u00e9tica como cura para a surdez"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1425\" class=\"elementor elementor-1425\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6339162d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6339162d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6aa78706\" data-id=\"6aa78706\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-741b7d5 elementor-widget elementor-widget-heading\" data-id=\"741b7d5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">BioNOW! #13 - Terapia gen\u00e9tica como cura para a surdez<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12599fd elementor-widget elementor-widget-text-editor\" data-id=\"12599fd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\"><\/span><span data-ccp-props=\"{\" 201341983=\"\" :0=\"\" 335551550=\"\" :6=\"\" 335551620=\"\" 335559739=\"\" :160=\"\" 335559740=\"\" :259=\"\">Uma muta\u00e7\u00e3o gen\u00e9tica rara, descoberta muito recentemente, pode levar \u00e0 gradual perda de audi\u00e7\u00e3o em crian\u00e7as devido a degenera\u00e7\u00e3o de c\u00e9lulas no ouvido. Uma nova terapia gen\u00e9tica apresenta potencial para curar esta surdez.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ee8570 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ee8570\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f50abbd\" data-id=\"f50abbd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-00b4f63 elementor-widget elementor-widget-text-editor\" data-id=\"00b4f63\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Uma equipa da Universidade de Telavive desenvolveu um m\u00e9todo inovador para combater a surdez em indiv\u00edduos com muta\u00e7\u00f5es no gene SYNE4. Esta muta\u00e7\u00e3o \u00e9 s\u00f3 uma de muitas j\u00e1 conhecidas que causam surdez em crian\u00e7as \u2013 cerca de 2 em 1000 crian\u00e7as nascem com alguma forma de defici\u00eancia auditiva.<\/p><p>A muta\u00e7\u00e3o no gene SYNE4 causa um defeito na forma das c\u00e9lulas ciliadas do ouvido interno, que leva a que estas n\u00e3o se desenvolvam corretamente, e n\u00e3o possam realizar as suas fun\u00e7\u00f5es necess\u00e1rias para a audi\u00e7\u00e3o.<\/p><p>A equipa criou um v\u00edrus sint\u00e9tico inofensivo, e equipou-o com uma vers\u00e3o normal do gene alvo. Ao injetar o v\u00edrus no ouvido interno, este infeta as c\u00e9lulas ciliadas e liberta o seu material gen\u00e9tico. A vers\u00e3o mutada do gene presente nestas c\u00e9lulas \u00e9 gradualmente substitu\u00edda pelo gene transportado pelo v\u00edrus, e o defeito nas c\u00e9lulas \u00e9 gradualmente reparado, permitindo que elas se desenvolvam e reproduzam corretamente.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4382550 elementor-widget elementor-widget-image\" data-id=\"4382550\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"550\" height=\"400\" src=\"https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2021\/01\/bionow_13_image_1.jpg\" class=\"attachment-full size-full wp-image-1429\" alt=\"\" srcset=\"https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2021\/01\/bionow_13_image_1.jpg 550w, https:\/\/nebfeupicbas.pt\/wp-content\/uploads\/2021\/01\/bionow_13_image_1-300x218.jpg 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c82a79 elementor-widget elementor-widget-text-editor\" data-id=\"8c82a79\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Figura 1 &#8211; Representa\u00e7\u00e3o esquem\u00e1tica do procedimento efetuado.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02d226b elementor-widget elementor-widget-text-editor\" data-id=\"02d226b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span data-contrast=\"auto\" class=\"TextRun SCXW207462565 BCX2\" xml:lang=\"PT-PT\" lang=\"PT-PT\"><span class=\"NormalTextRun SCXW207462565 BCX2\"><\/span><\/span><span data-contrast=\"auto\" class=\"TextRun SCXW207462565 BCX2\" xml:lang=\"PT-PT\" lang=\"PT-PT\"><span class=\"NormalTextRun SCXW207462565 BCX2\">Os testes realizados em ratos apresentam resultados promissores \u2013 ratos que nasceram com a muta\u00e7\u00e3o gen\u00e9tica conseguiram recuperar a sua audi\u00e7\u00e3o ap\u00f3s o tratamento, com uma sensibilidade quase igual \u00e0 de ratos saud\u00e1veis. Se este tratamento mostrar os mesmos resultados em humanos, pode vir a ser a chave para curar surdez causada por esta muta\u00e7\u00e3o, e por outras semelhantes.<\/span><\/span><\/p><p>Sabe mais em:<br \/><a href=\"http:\/\/dx.doi.org\/10.15252\/emmm.202013259\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.15252\/emmm.202013259<\/a><br \/><a href=\"https:\/\/english.tau.ac.il\/news\/gene-therapy-for-deafness\" target=\"_blank\" rel=\"noopener\">https:\/\/english.tau.ac.il\/news\/gene-therapy-for-deafness<\/a>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Uma muta\u00e7\u00e3o gen\u00e9tica rara, descoberta muito recentemente, pode levar \u00e0 gradual perda de audi\u00e7\u00e3o em crian\u00e7as devido a degenera\u00e7\u00e3o de c\u00e9lulas no ouvido. Uma nova terapia gen\u00e9tica apresenta potencial para curar esta surdez.<\/p>\n","protected":false},"author":168,"featured_media":1431,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-1425","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bionow"],"_links":{"self":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts\/1425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/users\/168"}],"replies":[{"embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1425"}],"version-history":[{"count":2,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts\/1425\/revisions"}],"predecessor-version":[{"id":1430,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/posts\/1425\/revisions\/1430"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=\/wp\/v2\/media\/1431"}],"wp:attachment":[{"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1425"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1425"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebfeupicbas.pt\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}